“Who would have thought,” said Tuszynski. Using a mouse model, Tuszynski and colleagues discovered that after injury, mature neurons in adult brains revert back to an embryonic state. This gives us fundamental insight into how, at a transcriptional level, regeneration happens,” said senior author Mark Tuszynski, MD, PhD, professor of neuroscience and director of the Translational Neuroscience Institute at UC San Diego School of Medicine. “Using the incredible tools of modern neuroscience, molecular genetics, virology and computational power, we were able for the first time to identify how the entire set of genes in an adult brain cell resets itself in order to regenerate. ![]() The new study lays out a “transcriptional roadmap of regeneration in the adult brain.” Until relatively recently, it seemed an impossible task. Repairing damage to the brain and spinal cord may be medical science’s most daunting challenge. ![]() The scientists report that in their newly adopted immature state, the cells become capable of re-growing new connections that, under the right conditions, can help to restore lost function. ![]() When adult brain cells are injured, they revert to an embryonic state, according to new findings published in the Apissue of Nature by researchers at University of California San Diego School of Medicine, with colleagues elsewhere.
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